diff --git a/manifests/s/Schrodinger/Pymol/2.4.1/Schrodinger.Pymol.yaml b/manifests/s/Schrodinger/Pymol/2.4.1/Schrodinger.Pymol.yaml
new file mode 100644
index 000000000..ac8a66427
--- /dev/null
+++ b/manifests/s/Schrodinger/Pymol/2.4.1/Schrodinger.Pymol.yaml
@@ -0,0 +1,24 @@
+PackageIdentifier: Schrodinger.Pymol
+PackageName: Pymol
+Moniker: Pymol
+PackageVersion: 2.4.1
+Publisher: Schrodinger
+License: Copyright (C) Schrodinger, LLC.
+LicenseUrl: https://github.com/schrodinger/pymol-open-source/blob/master/LICENSE
+PackageUrl: https://pymol.org/2/#download
+ShortDescription: A comprehensive software package for rendering and animating 3D structures.
+Tags:
+  - bioinformatics
+InstallerType: exe
+InstallerSwitches:
+  Custom: /InstallationType=JustMe /AddToPath=0 /RegisterPython=0
+  Silent: /S
+  SilentWithProgress: /S
+Installers:
+  - Architecture: x64
+    Scope: user
+    InstallerUrl: https://pymol.org/installers/PyMOL-2.4.1_198-Windows-x86_64.exe
+    InstallerSha256: 309DCC9790F2C2E45ECB397312B5F7948AABD509D9428CA4A72D6F15CEFE6459
+PackageLocale: en-US
+ManifestType: singleton
+ManifestVersion: 1.0.0